Gout / Hyperuricemia: Overview
Known as "the disease of kings and the king of diseases", gout has been studied by physicians and has caused suffering in countless humans since at least the days of Hippocrates.
Alternate Names : Gouty arthritis - acute, Gout - acute, , Tophaceous gout, Tophi, Podagra, Gout - chronic, Chronic gout, Acute gout, Acute gouty arthritis
hyperuricemia A buildup of uric acid (a byproduct of metabolism) in the blood; a side effect of some anticancer drugs.
hypervascular Having a large number of blood vessels.
or acute gout may be precipitated in certain patients receiving thiazide diuretics. Bisoprolol, alone or in combination with HCTZ, has been associated with increases in uric acid. However, in U.S.
Hyperuricemia: Abnormally elevated blood level of uric acid. Uric acid is a breakdown product of purines that are part of many foods we eat.
is the underlying cause of gout. This can occur for a number of reasons, including diet, genetic predisposition, or under excretion of urate (the salts of uric acid).
Hyperuricemia is caused by an imbalance in the production and excretion of urate, i.e., overproduction, underexcretion or both. Underexcretion is the most common cause, thought to account for 80-90% of hyperuricemia. (3) ...
is the disorder that occurs when you have too much uric acid in the body. Increased cell death, because of cancer or cancer treatments, can also lead to an accumulation of uric acid in the body.
Presence of uric acid crystals in joint fluid
More than one attack of acute arthritis ...
Rates Remain High Among U.S. Adults And Senior Citizens Placing Them At Risk For Developing Gout
The Number Of People With Gout Continues To Rise ...
Hyperuricemia (high level of uric acid in the blood)
Uric acid crystals in joint fluid
More than one attack of acute arthritis
Arthritis that develops in 1 day, producing a swollen, red, and warm joint ...
(> 15 mg/dL)
Hyperphosphatemia (> 8 mg/dL)
Allopurinol Some Trade Names
Click for Drug Monograph ...
Note: Hyperuricemia does not inevitably lead to gout. In fact, less than 20% of cases turn out to be full-blown arthritic gout disease.
Symptoms of Acute Gouty Arthritis ...
Uric Acid and . Purines in the liver produce uric acid. The uric acid enters the bloodstream, and most of it eventually goes through the kidneys and is excreted in the urine.
Metabolic: hyperuricemia, diabetes mellitus
Musculoskeletal: joint pain, myalgia, osteonecrosis, osteoporosis (with long-term use in children) ...
Chronic subclinical lead exposure is associated with interstitial nephritis, tubular damage (with tubular inclusion bodies), (with an increased risk of gout), ...
Most people with hyperuricemia never develop gout, and people with gout may have varying levels of uric acid in their blood.
Synovial Fluid Analysis ...
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(HY-per-yur-ih-SEE-mee-uh) A buildup of uric acid (a byproduct of metabolism) in the blood. is a side effect of some anticancer drugs.
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: Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients With leukemia or lymphoma. J Clin Oncol 19 (3): 697-704, 2001.
Goldman SC, Holcenberg JS, Finklestein JZ, et al.
On the other hand, some people may only develop elevated blood uric acid levels () without having manifestations of gout, such as arthritis or kidney problems.
Familial Nephropathy Associated with Hyperuricemia
Familial Nephropathy with Gout
Familial Nonhemolytic Jaundice
Familial Nonhemolytic Unconjugated Hyperbilirubinemia
Familial Nuchal Bleb
Familial Paroxysmal Polyserositis ...
If there is an increase in the production of uric acid or if the kidneys do not eliminate enough uric acid from the body, levels of it build up in the blood (a condition called ).
The presence of increased uric acid (a breakdown product of DNA) in the body distinguishes gout from other forms of arthritis, although hyperuricemia alone, which often occurs in the complete absence of gout, ...
Definition Anti-hyperuricemic drugs are used to treat , the state of having too much uric acid in the blood.
Some people may only develop elevated blood uric acid levels (hyperuricemia) without having arthritis or kidney problems.
Gout is characterized by , recurrent acute arthritis and, often deposition of urates in the skin as nodules, known as gouty tophi; yellow red papules tending to coalesce into multilocular nodules and plaques, ...
Although most people with gout have hyperuricemia, about 3 in 10 turn out to have normal uric acid levels during an actual attack.
If you have gout and , your body doesn't eliminate enough uric acid.
Risk Factors TOP
These factors increase your chance of developing gout. All causes of are risk factors for gout.
In gout, there are frequently, but not always, elevated levels of uric acid in the blood (hyperuricemia). However, only a small portion of those with hyperuricemia will develop gout.
Search results Medical News for - Uric acid ...
On the most basic level, gout is caused by too much uric acid in the blood, a condition called .
Gout - Gout and hyperuricemia are caused by uric acid crystals building up in the body. Gout symptoms and signs include joint pain and swelling. Read about treatment and foods to avoid.
didanosine, zalcitabine, stavudine, lamivudine, abacavir, emtricitabine) uniformly manifests as type-B lactic acidosis. However, didanosine may cause electrolyte abnormalities, such as hypokalemia, hyponatremia, hypermagnesemia, and , ...
Animal proteins, arthritis, corticosteroids, gouty arthritis, kidney disease, kidney failure, kidney stones, hyperuricemia, nonsteroidal anti-inflammatory drugs, NSAIDs, podagra, pseudogout, purines, tophi, urate crystals, uric acid.
Other clinical manifestations include , intellectual disability, a dystonic movement disorder that may be accompanied by choreoathetosis and spasticity, dysarthric speech, and compulsive self-biting, ...
Allopurinol can be given to prevent hyperuricemia, a relatively uncommon finding. Prognosis is poor if anemia, thrombocytopenia, neutropenia, bulky lymphadenopathy, and severe lymphocytosis are present.
They can also have a buildup of lactic acid in the body (lactic acidosis), high blood levels of a waste product called uric acid (), and excess amounts of fats in the blood (hyperlipidemia).
Blood tests may also reveal high cholesterol, high fats (hyperlipidemia), and elevated uric acid levels (hyperuricemia). Thyroid-stimulating hormone (TSH) should be measured to exclude thyroid deficiency.
Malignancy may lead to pain, wasting, neuropathy, nausea, anorexia, seizures, hypercalcemia, , obstruction, and organ failure.
See also: Gout, Kidney, Arthritis, Vomiting, Cancer